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Article

Properdin and Factor H: Opposing Players on the Alternative Complement Pathway “See-Saw”

1 Jan 2013

Abstract excerpt

Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway. Properdin up-regulates the alternative pathway by stabilizing the C3bBb complex, whereas factor H downregulates the pathway by promoting proteolytic degradation of C3b. While factor H is mainly produced in the liver, there are several extrahepatic sources. In addition to the liver, factor H is...

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Identifiers

PMID: 23630525
DOI: 10.3389/fimmu.2013.00093

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