Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of complement in the development of autoimmunity.

Current directions in autoimmunity - 1 Jan 2003

Boackle Susan A, Holers V Michael

Abstract excerpt

B cell complement receptors have been shown to be important in the generation of normal humoral immune responses, and they likely also participate in the development of autoimmunity. Complement component and receptor deficiencies have been associated with SLE in both animal models and patients with disease. Recent data suggest that Cr2 is a lupus susceptibility gene in the NZM2410 mouse model for lupus, as it...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Formation
Share to Autoantigens
Share to Complement Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement System Proteins

Share to Lymphocyte Subsets

Share to Receptors, Complement

Share to Receptors, Complement 3b

Share to Receptors, Complement 3d

Source

Identifiers

PMID: 12408051
DOI: 10.1159/000066860

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of complement in the development of autoimmunity.PMID 12408051Read ↗

Complement and autoimmunity.Semantic proximity Read ↗

Complement deficiency and autoimmunity.Semantic proximity Read ↗

The complement system in systemic lupus erythematosus: an update.Semantic proximity Read ↗

Complement deficiencies in humans and animals: Links to autoimmunitySemantic proximity Read ↗

Systemic lupus erythematosus as the paradigm for understanding the complex immune relationships and therapeutic opportunities for targeting complement in autoimmune diseasesSemantic proximity Read ↗

The complement system in lupus nephritisSemantic proximity Read ↗

Systemic lupus erythematosus and complement deficiency: clues to a novel role for the classical complement pathway in the maintenance of immune toleranceSemantic proximity Read ↗

A role for the Cr2 gene in modifying autoantibody production in systemic lupus erythematosus.Semantic proximity Read ↗

Systemic Lupus Erythematosus and Deficiencies of Early Components of the Complement Classical PathwaySemantic proximity Read ↗

The Role of Complement in the Development of Systemic Lupus ErythematosusSemantic proximity Read ↗

Role of complement receptor 2 in the pathogenesis of systemic lupus erythematosus.Semantic proximity Read ↗

Targeting the Immune Complex–Bound Complement C3d Ligand as a Novel Therapy for LupusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.