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Article

Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement.

Blood - 15 Jan 2008

Kimura Yuko, Miwa Takashi, Zhou Lin, Song Wen-Chao

Abstract excerpt

Properdin is a positive regulator of alternative pathway (AP) complement. The current understanding of properdin function is that it facilitates AP complement activation by stabilizing the C3 convertase C3bBb. Properdin-deficient patients are susceptible to lethal meningococcal infection, but the mechanism of this selective predisposition is not fully understood. By gene targeting in the mouse, we show here that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17916747
DOI: 10.1182/blood-2007-05-089821
PMCID: PMC2200840

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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