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Properdin deficiency associated with recurrent otitis media and pneumonia, and identification of male carrier with Klinefelter syndrome.

Clinical immunology (Orlando, Fla.) - 1 Jun 2009

Schejbel Lone, Rosenfeldt Vibeke, Marquart Hanne, Valerius Niels Henrik, Garred Peter

Abstract excerpt

Properdin is an initiator and stabilizer of the alternative complement activation pathway (AP). Deficiency of properdin is a rare X-linked condition characterized by increased susceptibility to infection with Neisseria meningitidis associated with a high mortality rate. We report properdin deficiency in a large Pakistani family. The index cases were found by screening for immunodeficiency due to a history of...

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Identifiers

PMID: 19328743
DOI: 10.1016/j.clim.2009.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Properdin deficiency associated with recurrent otitis media and pneumonia, and identification of male carrier with Klinefelter syndrome.PMID 19328743Read ↗

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Properdin deficiency and meningococcal disease—identifying those most at riskSemantic proximity Read ↗

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Properdin deficiency: molecular basis and disease association.Semantic proximity Read ↗

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