Article

Neoantigens recognized by T and B cells are generated by aberrant mRNA splicing in lupus neutrophils

2025-09-26

Abstract excerpt

<title>Abstract</title> <p>Proteome diversity is generated through alternative mRNA splicing1. In tumors, mis-spliced transcripts that contain intronic sequences, skipped exons, or noncanonical donor/acceptor splice junctions resulting in frame-shifts are often translated into neoantigens that drive anti-tumor immunity2,3. Here we report that neutrophils from patients with systemic lupus erythematosus (SLE), unli...

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Literature Corpus work: 7b2a4313-8f61-545b-82e9-0aabc20078a9
DOI: 10.21203/rs.3.rs-7668471/v1

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