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LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3

15 Jun 2023

Abstract excerpt

The RNA-binding protein LIN28B is overexpressed in over 30% of patients with colorectal cancer (CRC) and is associated with poor prognosis. In the present study, we unraveled a potentially novel mechanism by which LIN28B regulates colonic epithelial cell-cell junctions and CRC metastasis. Using human CRC cells (DLD-1, Caco-2, and LoVo) with either knockdown or overexpression of LIN28B, we identified claudin 1...

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PMID: 37318881
DOI: 10.1172/jci.insight.167310

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