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The Expression of the Claudin Family of Proteins in Colorectal Cancer

24 Feb 2024

Abstract excerpt

Claudins (CLDN1-CLDN24) are a family of tight junction proteins whose dysregulation has been implicated in tumorigeneses of many cancer types. In colorectal cancer (CRC), CLDN1, CLDN2, CLDN4, and CLDN18 have been shown to either be upregulated or aberrantly expressed. In the normal colon, CLDN1 and CLDN3-7 are expressed. Although a few claudins, such as CLDN6 and CLDN7, are expressed in CRC their levels are...

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Barrier Structure and Function Studies
Ferroptosis and cancer prognosis
Neurological Disease Mechanisms and Treatments

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38540693
DOI: 10.3390/biom14030272

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