Article

MiR-26b-5p-Modified hUB-MSCs Derived Exosomes Attenuate Early Brain Injury During Subarachnoid Hemorrhage via MAT2A-Mediated the p38 MAPK/STAT3 Signaling Pathway

2021-05-28

Abstract excerpt

<title>Abstract</title> <p>Early brain injury (EBI) is a major cause of adverse outcomes following subarachnoid hemorrhage (SAH). There is evidence that mesenchymal stem cells (MSCs) - derived exosomes are involved in the repair of SAH. Exosomes were extracted from human umbilical cord mesenchymal stem cells (hubMSCs) and identified. OxyHb treated PC12 cells were transfected with exosomes alone or together with m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7afd33e0-622b-5134-bd31-868655261955
DOI: 10.21203/rs.3.rs-446068/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MiR-26b-5p-Modified hUB-MSCs Derived Exosomes Attenuate Early Brain Injury During Subarachnoid Hemorrhage via MAT2A-Mediated the p38 MAPK/STAT3 Signaling PathwayDOI 10.21203/rs.3.rs-446068/v1Read

Dental pulp mesenchymal stem cell-derived exosomes inhibit neuroinflammation and microglial pyroptosis in subarachnoid hemorrhage via the miRNA-197-3p/Foxo3 axisSemantic proximity Read

Microglia-derived iron-overloaded exosomes induce neuronal ferroptosis and aggravate neurological impairment after subarachnoid hemorrhageSemantic proximity Read

MicroRNAs Role in Diagnosis and Treatment of Subarachnoid HemorrhageSemantic proximity Read

Mesenchymal stem cell-derived extracellular vesicles promote microglial M2 polarization after subarachnoid hemorrhage in rats and involve the AMPK/NF-κB signaling pathway.Semantic proximity Read

Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injurySemantic proximity Read

MFG-E8 attenuates neuro-inflammation in subarachnoid hemorrhage through driving microglial M2 polarization via modulating Integrin β3/SOCS3/STAT3 signaling pathwaySemantic proximity Read

Exosomal microRNA-22-3p alleviates cerebral ischemic injury by modulating KDM6B/BMP2/BMF axisSemantic proximity Read

MicroRNA-29a-5p attenuates hemorrhagic transformation and improves outcomes after mechanical reperfusion for acute ischemic strokeSemantic proximity Read

Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repairSemantic proximity Read

RNA-seq Identifies FOS as a Potential Therapeutic Target Activating Neural Stem Cells via miR-21/SOX2 Pathway in Hypertensive Intracerebral HemorrhageSemantic proximity Read

Astrocyte-derived exosomal lncRNA 4933431K23Rik modulates microglial phenotype and improves post-traumatic recovery via SMAD7 regulation.Semantic proximity Read

UPR Responsive Genes Manf and Xbp1 in StrokeSemantic proximity Read