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Astrocyte-derived exosomal lncRNA 4933431K23Rik modulates microglial phenotype and improves post-traumatic recovery via SMAD7 regulation.

Molecular therapy : the journal of the American Society of Gene Therapy - 3 May 2023

He Xuejun, Huang Yimin, Liu Yuan, Zhang Xincheng, Wang Quanji, Liu Yanchao, Ma Xiaopeng, Long Xiaobing, Ruan Yang, Lei Hongxia, Gan Chao, Wang Xiaochuan, Zou Xin, Xiong Bo, Shu Kai, Lei Ting, Zhang Huaqiu

Abstract excerpt

Astrocyte-microglial interaction plays a crucial role in brain injury-associated neuroinflammation. Our previous data illustrated that astrocytes secrete microRNA, leading to anti-inflammatory effects on microglia. Long non-coding RNAs participate in neuroinflammation regulation after traumatic brain injury. However, the effect of astrocytes on microglial phenotype via long non-coding RNAs and the underlying...

Topics

Mice
Animals
Microglia
RNA, Long Noncoding
Astrocytes
Neuroinflammatory Diseases
MicroRNAs
Brain Injuries, Traumatic
Phenotype
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36739479
DOI: 10.1016/j.ymthe.2023.01.031
PMCID: PMC10188635

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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