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Article

The emerging roles of TCF4 in disease and development.

Trends in molecular medicine - 1 Jun 2014

Forrest Marc P, Hill Matthew J, Quantock Andrew J, Martin-Rendon Enca, Blake Derek J

Abstract excerpt

Genome-wide association studies have identified common variants in transcription factor 4 (TCF4) as susceptibility loci for schizophrenia, Fuchs' endothelial corneal dystrophy, and primary sclerosing cholangitis. By contrast, rare TCF4 mutations cause Pitt-Hopkins syndrome, a disorder characterized by intellectual disability and developmental delay, and have also been described in patients with other...

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Source

Identifiers

PMID: 24594265
DOI: 10.1016/j.molmed.2014.01.010

Genes

TCF4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CTCF mutation at R567 causes developmental disorders via 3D genome rearrangement and abnormal neurodevelopment.Semantic proximity Read ↗

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