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Article

Localized structural frustration for evaluating the impact of sequence variants.

Nucleic acids research - 1 Dec 2016

Kumar Sushant, Clarke Declan, Gerstein Mark

Abstract excerpt

Population-scale sequencing is increasingly uncovering large numbers of rare single-nucleotide variants (SNVs) in coding regions of the genome. The rarity of these variants makes it challenging to evaluate their deleteriousness with conventional phenotype-genotype associations. Protein structures provide a way of addressing this challenge. Previous efforts have focused on globally quantifying the impact of SNVs...

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PMID: 27915290
DOI: 10.1093/nar/gkw927
PMCID: PMC5137452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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