Article

Perfluorooctanoic Acid Promotes Pancreatic Β Cell Dysfunction and Apoptosis Through ER Stress and the ATF4/CHOP/TRIB3 Pathway

2021-12-02

Abstract excerpt

Perfluorooctanoic acid (PFOA), a widely used chemical substance, causes an increased risk of human type 2 diabetes (T2D) through a currently unknown mechanism. The aim of the present study was to investigate whether PFOA regulates the functions of pancreatic β cells, which are specialized for biosynthesis and secretion of insulin, and to reveal the underlying mechanism. Treatment of the MIN6 β-cell line with PFOA...

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Literature Corpus work: 7ac0ddbf-d8b5-53a4-8b4e-6047788a946c
DOI: 10.21203/rs.3.rs-1022358/v1

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