Article
Evolutionary models of quantitative disease risk factors.
Human biology - 1 Dec 1993
Connor A, Weiss K M, Weeks S C
Abstract excerpt
Numerous mutations are now known that have significant effects on various phenotypes; many of these mutations are of interest because they influence quantitative risk factors for major diseases. Such diversity raises the question of how much genetic heterogeneity we should expect to find in the effects of alleles, that is, the size of the effects, the number of severe alleles, and their frequency in the...
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