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Meta-SAIGE: Scalable and Accurate Meta-Analysis for Rare Variants

2024-09-19

Abstract excerpt

A meta-analysis is a practical approach to increasing the power of rare variant tests by combining summary statistics from multiple cohorts. However, existing methods for rare variant meta-analysis often fail to correctly control type I error rates when analyzing low-prevalence binary traits and are computationally intensive when analyzing many phenotypes. This paper introduces Meta-SAIGE, a novel approach for rar...

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Literature Corpus work
7aa4b3e7-82d8-5297-9f2f-8482d68ae205
DOI
10.1101/2024.09.17.24313855
Open publication

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Meta-SAIGE: Scalable and Accurate Meta-Analysis for Rare VariantsDOI 10.1101/2024.09.17.24313855
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