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Article

PreMeta: a tool to facilitate meta-analysis of rare-variant associations.

BMC genomics - 14 Feb 2017

Tang Zheng-Zheng, Bunn Paul, Tao Ran, Liu Zhouwen, Lin Dan-Yu

Abstract excerpt

BACKGROUND: Meta-analysis is essential to the discovery of rare variants that influence complex diseases and traits. Four major software packages, namely MASS, MetaSKAT, RAREMETAL, and seqMeta, have been developed to perform meta-analysis of rare-variant associations. These packages first generate summary statistics for each study and then perform the meta-analysis by combining the summary statistics. Because of...

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PMID: 28196472
DOI: 10.1186/s12864-017-3573-1
PMCID: PMC5310051

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