Article

Post-transcriptional Regulation is the Major Driver of microRNA Expression Variation

2020-01-08

Abstract excerpt

MicroRNA (miRNA) expression patterns are highly variable across human tissues and across cancer specimens. The intuitive assumption is that transcription is the main contributor to mature miRNA expression patterns, with post-transcriptional processes further modifying miRNA expression levels. Here we report the surprising model that, on the global level, post-transcriptional regulation dominates over transcription...

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Literature Corpus work: 7a980594-397f-5ab5-90dc-3b0fd1d9c053
DOI: 10.1101/2020.01.07.897975

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