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Yangpumicins F and G, Enediyne Congeners from Micromonospora yangpuensis DSM 45577

6 Sept 2019

Abstract excerpt

Enediyne natural products are among the most cytotoxic small molecules and thus excellent payload candidates for the development of antibody–drug conjugates (ADCs). Here we report the isolation and structural elucidation of two new 10-membered anthraquinone-fused enediynes, yangpumicins (YPM) F ( 6 ) and G ( 7 ), together with five known congeners, YPM A–E ( 1 – 5 ), from Micromonospora yangpuensis DSM 45577. YPM...

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PMID: 31490685
DOI: 10.1021/acs.jnatprod.9b00229

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