Article

PARP inhibition causes premature loss of cohesion in cancer cells

2017-06-22

Abstract excerpt

<h4>ABSTRACT</h4> Poly(ADP-ribose) polymerases (PARPs) regulate various aspects of cellular function including mitotic progression. Although PARP inhibitors have been undergoing various clinical trials and the PARP1/2 inhibitor olaparib was approved as monotherapy for BRCA-mutated ovarian cancer, their mode of action in killing tumour cells is not fully understood. We investigated the effect of PARP inhibition on...

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Literature Corpus work: 7a620b46-0872-5d39-8a83-e4d6df9778b2
DOI: 10.1101/153932

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