Replication-induced DNA damage after PARP inhibition causes G 2 delay, and cell line-dependent apoptosis, necrosis and multinucleation

Abstract excerpt

PARP inhibitors have been approved for treatment of tumors with mutations in or loss of BRCA1/2. The molecular mechanisms and particularly the cellular phenotypes resulting in synthetic lethality are not well understood and varying clinical responses have been observed. We have investigated the dose- and time-dependency of cell growth, cell death and cell cycle traverse of 4 malignant lymphocyte cell lines...

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