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PARG inhibition induces replication catastrophe in ovarian cancer cells with down-regulated DNA replication genes

2020-07-13

Abstract excerpt

<h4>Summary</h4> The discovery that PARP1/2 inhibitors selectively kill BRCA mutant cells has led to a paradigm shift in the treatment of women with homologous recombination (HR)-deficient high-grade serous ovarian cancer (HGSOC), driving unprecedented improvements in progression-free and, more recently, overall survival. However, because most HGSOC cases are not HR-defective, and are therefore unlikely to benef...

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Literature Corpus work
e51b686d-2a94-5a39-a5ac-ff1a737d49f2
DOI
10.1101/2020.07.13.199968
Open publication

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PARG inhibition induces replication catastrophe in ovarian cancer cells with down-regulated DNA replication genesDOI 10.1101/2020.07.13.199968
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