Article

Modeling Pulmonary Cystic Fibrosis in a Human Lung Airway-on-a-chip

2021-07-19

Abstract excerpt

<h4>Background</h4> Cystic fibrosis (CF) is a genetic disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), which results in impaired airway mucociliary clearance, inflammation, infection, and respiratory insufficiency. The development of new therapeutics for CF are limited by the lack of reliable preclinical models that recapitulate the structural, immuno...

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Literature Corpus work: 7a2c577b-f7dc-59dd-93c1-9e2e54ba4ab0
DOI: 10.1101/2021.07.15.21260407

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