Article

Human induced pluripotent stem cells for in vitro modeling of impaired mucociliary clearance in cystic fibrosis lung disease

2025-09-04

Abstract excerpt

<title>Abstract</title> <p>Severely impaired mucociliary airway function is the primary pathomechanism in Cystic Fibrosis (CF) lung disease. Despite significant advances in CF therapy, there is still a critical need for alternative, individualized treatment options, especially for patients with untreatable CFTR mutations.Although intestinal organoids and primary airway cells are widely used as preclinical models...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a0cd6efd-173e-5505-b95a-29b769f7869a
DOI: 10.21203/rs.3.rs-7184232/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human induced pluripotent stem cells for in vitro modeling of impaired mucociliary clearance in cystic fibrosis lung diseaseDOI 10.21203/rs.3.rs-7184232/v1Read

Advances in Preclinical In Vitro Models for the Translation of Precision Medicine for Cystic FibrosisSemantic proximity Read

Airway and lung organoids from human induced pluripotent stem cells can be used to assess CFTR conductanceSemantic proximity Read

Generation of Airway Epithelial Cell Air-Liquid Interface Cultures from Human Pluripotent Stem CellsSemantic proximity Read

In vitro platform to model the function of ionocytes in the human airway epitheliumSemantic proximity Read

A molecular atlas of proximal airway identifies subsets of known airway cell types revealing details of the unique molecular pathogenesis of Cystic FibrosisSemantic proximity Read

Challenges Facing Airway Epithelial Cell-Based Therapy for Cystic FibrosisSemantic proximity Read

Personalized medicine for cystic fibrosis: establishing human model systems.Semantic proximity Read

Modeling Pulmonary Cystic Fibrosis in a Human Lung Airway-on-a-chipSemantic proximity Read

Human pluripotent stem cells for the modelling and treatment of respiratory diseasesSemantic proximity Read

A new platform for high-throughput therapy testing on iPSC-derived, immature airway from Cystic Fibrosis PatientsSemantic proximity Read

Differentiation of human induced pluripotent stem cells into functional airway epitheliumSemantic proximity Read

Pharmacological correction of CFTR improves systemic inflammation and lung disease in Cystic Fibrosis but does not correct a basic defect in lung repairSemantic proximity Read