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Casein kinase 1D encodes a novel drug target in Hedgehog-GLI driven cancers and tumor-initiating cells resistant to SMO inhibition

2021-06-17

Abstract excerpt

(1) <h4>Background</h4> Aberrant activation of the Hedgehog (HH)/GLI pathway in stem-like tumor initiating cells (TIC) is a frequent oncogenic driver signal in various human malignancies. Remarkable efficacy of anti-HH therapeutics led to the approval of HH inhibitors targeting the key pathway effector Smoothened (SMO) in basal cell carcinoma and acute myeloid leukemia. However, frequent development of drug resis...

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Literature Corpus work
7a26b43b-9ba3-5aff-9595-a96844ef2305
DOI
10.1101/2021.06.17.448773
Open publication

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Casein kinase 1D encodes a novel drug target in Hedgehog-GLI driven cancers and tumor-initiating cells resistant to SMO inhibitionDOI 10.1101/2021.06.17.448773
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