Article

The BMP4-BMPR1A axis represses BRCA1 in mammary stem cells and contributes to tumor initiation

2025-06-28

Abstract excerpt

Basal-like breast cancer (BLBC) is an aggressive subtype frequently characterized by homologous recombination deficiency (HRD) and BRCAness, even in the absence of BRCA1 mutations. Here, we identify the BMP4-BMPR1A signaling axis as a novel regulator of BRCA1 expression and a driver of BRCAness in non-transformed immature mammary cells. We observed that high BMPR1A expression is correlated with low BRCA1 levels an...

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Literature Corpus work: 7a1207e1-faf9-5739-a1f6-64637ef90e12
DOI: 10.1101/2025.06.27.661450

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