Article

The BMP4-BMPR1A axis represses BRCA1 in mammary stem cells and contributes to tumor initiation.

2026-01-16

Abstract excerpt

<title>Abstract</title> <p>Basal-like breast cancer (BLBC) is an aggressive subtype frequently characterized by homologous recombination deficiency (HRD) and BRCAness, even in the absence of BRCA1 mutations. Here, we identify the BMP4-BMPR1A signaling axis as a novel regulator of BRCA1 expression and a driver of BRCAness in non-transformed immature mammary cells. We observed that high BMPR1A expression is correla...

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Literature Corpus work: 2660b936-7bac-5cdd-9b04-f98483f05f80
DOI: 10.21203/rs.3.rs-8392937/v1

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