Article

Antibody targeting the anti-parallel topology of human telomeric G-quadruplex DNA

2025-05-15

Abstract excerpt

G-quadruplexes (G4s) are four-stranded nucleic acid structures that have gathered a significant attention due to their involvement in key biological processes, including gene regulation, genome stability, and telomeres maintenance. Some G4 antibodies have been developed to selectively recognize these structures over duplex DNA; however, most, even the widely studied BG4 and 1H6, bind G4s in a general manner and la...

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Literature Corpus work: 79fd33c8-7201-5ef9-bb2f-eb69f48ae2ad
DOI: 10.1101/2025.05.13.653741

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