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Article

Human knockout research: new horizons and opportunities.

Trends in genetics : TIG - 1 Feb 2015

Alkuraya Fowzan S

Abstract excerpt

Although numerous approaches have been pursued to understand the function of human genes, Mendelian genetics has by far provided the most compelling and medically actionable dataset. Biallelic loss-of-function (LOF) mutations are observed in the majority of autosomal recessive Mendelian disorders...

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Identifiers

PMID: 25497971
DOI: 10.1016/j.tig.2014.11.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25497971-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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