Article

Metabolic and imaging phenotypes associated with <i>RB1</i> and <i>TP53</i> loss in prostate cancer

2023-11-17

Abstract excerpt

Advanced prostate cancer is treated with androgen receptor (AR) signaling inhibitors, which are initially effective, but most patients eventually develop resistance and progress to castrate-resistant prostate cancer (CRPC). Loss of RB1 in CRPC tumors is correlated with rapid progression and poor patient survival and, in combination with TP53 loss, predisposes patients to the development of transitional neuroendocr...

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Literature Corpus work: 79f09fc4-7f0f-5c3e-96ff-81d763d40c33
DOI: 10.1101/2023.11.15.567250

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