Article
Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells.
Oncotarget - 20 Sept 2016
Ippolito Luigi, Marini Alberto, Cavallini Lorenzo, Morandi Andrea, Pietrovito Laura, Pintus Gianfranco, Giannoni Elisa, Schrader Thomas, Puhr Martin, Chiarugi Paola, Taddei Maria Letizia
Abstract excerpt
Drug resistance of cancer cells is recognized as the primary cause of failure of chemotherapeutic treatment in most human cancers. Growing evidences support the idea that deregulated cellular metabolism is linked to such resistance. Indeed, both components of the glycolytic and mitochondrial pathways are involved in altered metabolism linked to chemoresistance of several cancers. Here we investigated the...
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