Article

Targeting hepatocyte MagL regulates the progression of colorectal liver metastases during liver ischemia-reperfusion

2022-11-03

Abstract excerpt

<h4>Background: </h4> Colorectal cancer (CRC) commonly metastasizes. The liver is the most frequent site of metastases and dominates the length of survival for this disease. In such cases, surgical resection is usually the first choice of treatment, but postoperative recurrence is very common. To control hemorrhage, liver ischemia-reperfusion (LIR) becomes a common event during hepatic surgery. Many studies show t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 79e0355a-210f-5efe-803d-5c0fefa7bd20
DOI: 10.21203/rs.3.rs-2210265/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting hepatocyte MagL regulates the progression of colorectal liver metastases during liver ischemia-reperfusionDOI 10.21203/rs.3.rs-2210265/v1Read

PPARγ-dependent hepatic macrophage switching acts as a central hub for hUCMSCs-mediated alleviation of decompensated liver cirrhosis in ratsSemantic proximity Read

Liver prometastatic reaction: Stimulating factors and responsive cancer phenotypes.Semantic proximity Read

Perisurgical Colony Stimulating Factor 1 (CSF1) treatment ameliorates liver ischaemia/reperfusion injury in ratsSemantic proximity Read

New insights into colorectal cancer liver metastasis carcinogenesis and its effect with moxibustionSemantic proximity Read

TCF4 enhances hepatic metastasis of colorectal cancer by regulating tumor-associated macrophage via CCL2/CCR2 signaling.Semantic proximity Read

LRG1 is a novel HER3 ligand and promotes growth in colorectal cancerSemantic proximity Read

Coculturing liver cancer cells and monocytes in spheroids conditions monocytes to adopt tumor-associated macrophage phenotypes that favor tumor growth via cholesterol metabolism.Semantic proximity Read

Intestinal epithelium-derived high density lipoprotein restrains liver injury via the portal veinSemantic proximity Read

Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progressionSemantic proximity Read

Mechanisms of liver regeneration in a clinical model for preoperative induction of liver hypertrophy prior to major liver resectionSemantic proximity Read

Cyclooxygenase-2 is a target of KRASD12, which facilitates the outgrowth of murine C26 colorectal liver metastases.Semantic proximity Read

Plasmodium infection inhibits tumor angiogenesis through effects on tumor-associated macrophages in a murine implanted hepatoma modelSemantic proximity Read