Article

Intestinal epithelium-derived high density lipoprotein restrains liver injury via the portal vein

2020-10-02

Abstract excerpt

<h4>Summary</h4> Assembly of high density lipoprotein (HDL) requires apoA1 and the cholesterol transporter ABCA1. Although the liver generates most HDL in blood, HDL synthesis also occurs in the small intestine. However, distinct functions for intestinal HDL are unknown. Here we show that HDL in the portal vein, which connects intestine to liver, derivesd mainly from intestine and potently neutralizes lipopolysac...

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Literature Corpus work: 613fe9c2-1537-50c3-93d3-e0da3d434df3
DOI: 10.1101/2020.10.01.322925

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