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Uncovering the mode of action of engineered T cells in patient cancer organoids

25 Jul 2022

Abstract excerpt

Extending the success of cellular immunotherapies against blood cancers to the realm of solid tumors will require improved in vitro models that reveal therapeutic modes of action at the molecular level. Here we describe a system, called BEHAV3D, developed to study the dynamic interactions of immune cells and patient cancer organoids by means of imaging and transcriptomics. We apply BEHAV3D to live-track >150,000...

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PMID: 35879361
DOI: 10.1038/s41587-022-01397-w

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