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Reversal of Synapse Degeneration by Restoring Wnt Signaling in the Adult Hippocampus

9 Sept 2016

Abstract excerpt

Synapse degeneration occurs early in neurodegenerative diseases and correlates strongly with cognitive decline in Alzheimer's disease (AD). The molecular mechanisms that trigger synapse vulnerability and those that promote synapse regeneration after substantial synaptic failure remain poorly understood. Increasing evidence suggests a link between a deficiency in Wnt signaling and AD. The secreted Wnt antagonist...

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Identifiers

PMID: 27593374
DOI: 10.1016/j.cub.2016.07.024

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