Article

Investigation into the in vivo and in vitro effects of anti-angiogenic therapy on abdominal aortic aneurysms

2020-01-01

Abstract excerpt

Medical therapy to prevent abdominal aortic aneurysm (AAA) development and progression is not currently available. Angiogenesis and extracellular signal-related kinase (ERK) pathway are key modulators of matrix metallo proteinases (MMPs) during AAA formation. The aim of the study described in this thesis is to evaluate the effects of Sorafenib (a multikinase inhibitor with antiangiogenic and ERK inhibitory propert...

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Literature Corpus work: 79cc3379-ff3c-511a-bd5d-fbe47cce23a3
DOI: 10.25392/leicester.data.11792073.v1

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