Article
BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions.
eLife - 10 Jul 2018
Bery Nicolas, Cruz-Migoni Abimael, Bataille Carole Jr, Quevedo Camilo E, Tulmin Hanna, Miller Ami, Russell Angela, Phillips Simon Ev, Carr Stephen B, Rabbitts Terence H
Abstract excerpt
The RAS family of proteins is amongst the most highly mutated in human cancers and has so far eluded drug therapy. Currently, much effort is being made to discover mutant RAS inhibitors and in vitro screening for RAS-binding drugs must be followed by cell-based assays. Here, we have developed a robust set of bioluminescence resonance energy transfer (BRET)-based RAS biosensors that enable monitoring of...
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