Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.

doi:10.1038/s41556-021-00654-5

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Article

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.

Nature cell biology - 1 Apr 2021

Ponsioen Bas, Post Jasmin B, Buissant des Amorie Julian R, Laskaris Dimitrios, van Ineveld Ravian L, Kersten Simone, Bertotti Andrea, Sassi Francesco, Sipieter François, Cappe Benjamin, Mertens Sander, Verlaan-Klink Ingrid, Boj Sylvia F, Vries Rob G J, Rehmann Holger, Vandenabeele Peter, Riquet Franck B, Trusolino Livio, Bos Johannes L, Snippert Hugo J G

Abstract excerpt

Direct targeting of the downstream mitogen-activated protein kinase (MAPK) pathway to suppress extracellular-regulated kinase (ERK) activation in KRAS and BRAF mutant colorectal cancer (CRC) has proven clinically unsuccessful, but promising results have been obtained with combination therapies including epidermal growth factor receptor (EGFR) inhibition. To elucidate the interplay between EGF signalling and ERK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33795873
DOI: 10.1038/s41556-021-00654-5
PMCID: PMC7610573

Genes

EGFR
BRAF
KRAS
EGF

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