Article

MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions

2020-08-23

Abstract excerpt

<h4>ABSTRACT</h4> Maintenance of the pancreatic acinar cell phenotype suppresses tumor formation. Hence, repetitive acute or chronic pancreatitis, stress conditions in which the acinar cells dedifferentiate, predispose for cancer formation in the pancreas. Dedifferentiated acinar cells acquire a large panel of duct cell-specific markers. However, it remains unclear to what extent dedifferentiated acini differ fro...

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Literature Corpus work: 79bb15cb-dca1-526a-a1bc-ad703a34eb5f
DOI: 10.1101/2020.08.21.260539

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