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Article

MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions

24 Mar 2021

Abstract excerpt

Maintenance of the pancreatic acinar cell phenotype suppresses tumor formation. Hence, repetitive acute or chronic pancreatitis, stress conditions in which the acinar cells dedifferentiate, predispose for cancer formation in the pancreas. Dedifferentiated acinar cells acquire a large panel of duct cell-specific markers. However, it remains unclear to what extent dedifferentiated acini differ from native duct...

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PMID: 33762742
DOI: 10.1038/s41418-021-00771-6

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