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Cerebrovascular damage caused by the gut microbe/host co-metabolite <i>p</i> -cresol sulfate is prevented by blockade of the EGF receptor

2022-11-15

Abstract excerpt

Circulating levels of the gut microbe/host co-metabolite p-cresol sulfate (pCS) correlate with cerebrovascular event risk in individuals with chronic kidney disease, but whether this relationship is mechanistic is unclear. We hypothesised that pCS would impair function of the blood-brain barrier (BBB), the primary brain-vasculature interface. We report that pCS exposure impairs BBB integrity in human cells in vit...

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Identifiers and source

Literature Corpus work
79b8f0ff-238b-55a9-8465-6d976bca7022
DOI
10.1101/2022.11.12.516113
Open publication

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