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A host–gut microbial co-metabolite of aromatic amino acids, <i>p</i> -cresol glucuronide, promotes blood–brain barrier integrity <i>in vivo</i>

2022-01-12

Abstract excerpt

<h4>Purpose</h4> The sequential activity of gut microbial and host processes can exert a powerful modulatory influence on dietary components, as exemplified by the metabolism of the amino acids tyrosine and phenylalanine to p -cresol by gut microbes, and then to p -cresol glucuronide (pCG) by host enzymes. Although such glucuronide conjugates are classically thought to be biologically inert, there is accumulati...

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Literature Corpus work
21c66014-f569-568f-b656-3f3feaade363
DOI
10.1101/2022.01.11.475932
Open publication

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A host–gut microbial co-metabolite of aromatic amino acids, <i>p</i> -cresol glucuronide, promotes blood–brain barrier integrity <i>in vivo</i>DOI 10.1101/2022.01.11.475932
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