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Assessing the genetic contribution of cumulative behavioral factors associated with longitudinal type 2 diabetes risk highlights adiposity and the brain-metabolic axis

2024-01-31

Abstract excerpt

While genetic factors, behavior, and environmental exposures form a complex web of interrelated associations in type 2 diabetes (T2D), their interaction is poorly understood. Here, using data from ∼500K participants of the UK Biobank, we identify the genetic determinants of a “polyexposure risk score” (PXS) a new risk factor that consists of an accumulation of 25 associated individual-level behaviors and environme...

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Literature Corpus work
79b86b80-aa7b-5c1b-a9ca-d71f0803a08e
DOI
10.1101/2024.01.30.24302019
Open publication

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Assessing the genetic contribution of cumulative behavioral factors associated with longitudinal type 2 diabetes risk highlights adiposity and the brain-metabolic axisDOI 10.1101/2024.01.30.24302019
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