Associations of Combined Genetic and Lifestyle Risks With Incident Type 2 Diabetes in the UK Biobank.

doi:10.2337/db25-0672

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Associations of Combined Genetic and Lifestyle Risks With Incident Type 2 Diabetes in the UK Biobank.

Diabetes - 1 May 2026

Zhao Chi, Hatzikotoulas Konstantinos, Balasubramanian Raji, Bertone-Johnson Elizabeth, Cai Na, Huang Lianyun, Huerta-Chagoya Alicia, Janiczek Margaret, Ma Chaoran, Mandla Ravi, Paluch Amanda, Rayner Nigel W, Southam Lorraine, Sturgeon Susan R, Suzuki Ken, Taylor Henry J, Vankim Nicole, Yin Xianyong, Lee Chi Hyun, Collins Francis, Spracklen Cassandra N

Abstract excerpt

Type 2 diabetes (T2D) results from the interplay of genetic susceptibility and an unhealthy lifestyle, but their combined effects are not well studied. We examined whether unhealthy modifiable behaviors were associated with similar increases in the risk of incident T2D in individuals with different levels of genetic risk. Among 332,251 UK Biobank participants without diabetes, we constructed a multiancestry...

Topics

Humans
Diabetes Mellitus, Type 2
Female
Male
Life Style
Middle Aged
United Kingdom
Genetic Risk Score
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Factors

Incidence

Adult

Biological Specimen Banks

Aged

UK Biobank

Proportional Hazards Models

Exercise

Source

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Identifiers

PMID: 42008691
DOI: 10.2337/db25-0672
PMCID: PMC13097205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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