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Gene-Lifestyle Interplay in Type 1 Diabetes: Joint Effects and Interactions From Cross-Sectional and Longitudinal Cohort Analyses.

Diabetes/metabolism research and reviews - 1 May 2026

Lai Chunran, Li Qinyi, Geng Xingchen, Cao Jiahui, Zeng Xiaomin, Du Zijing, Wang Shan, Shen Chenxiao, Fang Ying, Hu Yijun, Shang Xianwen, Zhu Zhuoting, Zhang Xiayin, Yu Honghua

Abstract excerpt

BACKGROUND: Type 1 diabetes (T1D) is a complex autoimmune disorder heavily influenced by heritable traits. However, the interplay between modifiable lifestyle factors and genetic susceptibility remains insufficiently characterised. This study sought to elucidate how genetic background and lifestyle determinants jointly affect T1D liability. METHODS: Utilising the UK Biobank cohort, we performed both...

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PMID: 41983518
DOI: 10.1002/dmrr.70168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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