Article

Ovarian development is driven by early spatiotemporal priming of the coelomic epithelium

2025-09-25

Abstract excerpt

Ovarian organogenesis relies on the coordinated specification of supporting and steroidogenic lineages from multipotent coelomic epithelium (CE) progenitors. However, it remains unclear how ovarian cellular diversity arises and whether CE progenitors are fate-biased before or after ingression into the gonad. We show that CE cells in fetal mouse and human ovaries are transcriptionally heterogeneous and spatially or...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7995ac25-9bf9-5441-b2c0-a73371a414ef
DOI: 10.1101/2025.09.24.678234

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ovarian development is driven by early spatiotemporal priming of the coelomic epitheliumDOI 10.1101/2025.09.24.678234Read

Single-cell transcriptome landscape of developing fetal gonads defines somatic cell lineage specification in humansSemantic proximity Read

Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonadSemantic proximity Read

Temporal Differences in Granulosa Cell Specification in the Ovary Reflect Distinct Follicle Fates in Mice1Semantic proximity Read

Single-cell analysis of the developing human ovary defines distinct insights into ovarian somatic and germline progenitorsSemantic proximity Read

Ovarian Stem Cell Niche and Follicular Renewal in MammalsSemantic proximity Read

Spatial atlas of the ovary identifies molecular events in primordial follicle activation in humansSemantic proximity Read

Temporal Transcriptional Profiling of Somatic and Germ Cells Reveals Biased Lineage Priming of Sexual Fate in the Fetal Mouse GonadSemantic proximity Read

A spatiotemporal gene expression and cell atlases of the developing rat ovarySemantic proximity Read

Morphogenetic ovarian modules for oocyte production from germline stem cellsSemantic proximity Read

Single-cell roadmap of bovine oogenesis and somatic niche interactions during fetal ovarian developmentSemantic proximity Read

Defining the neighborhoods that escort the oocyte through its early life events and into a functional follicleSemantic proximity Read

Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristicsSemantic proximity Read