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Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics

18 Aug 2008

Abstract excerpt

Ovulation induces cyclic rupture and regenerative repair of the ovarian coelomic epithelium. This process of repeated disruption and repair accompanied by complex remodeling typifies a somatic stem/progenitor cell-mediated process. Using BrdU incorporation and doxycycline inducible histone2B-green fluorescent protein pulse-chase techniques, we identify a label-retaining cell population in the coelomic epithelium...

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PMID: 18711140
DOI: 10.1073/pnas.0805012105

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