Article

Spatial atlas of the ovary identifies molecular events in primordial follicle activation in humans

2026-06-08

Abstract excerpt

The human ovarian reserve is established prenatally, when granulosa cells encapsulate germ cells to form a pool of quiescent primordial follicles, that ultimately determines the female reproductive and endocrine lifespan. From birth to menopause, subsets of these quiescent follicles, located in the thin outer ovarian cortex, are activated and undergo a growth programme with progressive inward migration to the inne...

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Literature Corpus work: b5e1ff19-a214-536e-8a0b-dd0eb1df8a5d
DOI: 10.64898/2026.06.05.730381

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