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Article

Targeting Alternative Sites on the Androgen Receptor to Treat Castration-Resistant Prostate Cancer

14 Jun 2013

Abstract excerpt

Recurrent, metastatic prostate cancer continues to be a leading cause of cancer-death in men. The androgen receptor (AR) is a modular, ligand-inducible transcription factor that regulates the expression of genes that can drive the progression of this disease, and as a consequence, this receptor is a key therapeutic target for controlling prostate cancer. The current drugs designed to directly inhibit the AR are...

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PMID: 23771019
DOI: 10.3390/ijms140612496

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