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Ventral Hippocampal Infusions of C20:0 Ceramide Stimulate Microglia and Induce Anhedonia-like Behavior in Female and Male Rats

2022-04-22

Abstract excerpt

<h4>ABSTRACT</h4> Increased long-chain C20:0 ceramides have been found in the serum of patients with depression. Moreover, ceramides are linked with increased microglia reactivity and inflammatory cytokine production, which are associated with depression. Since ceramides can readily cross the blood brain barrier, peripheral C20:0 ceramides could enter the brain, activate microglia, and induce depressive-like beha...

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Literature Corpus work
79829873-8494-53d3-a2c6-18ea3c499010
DOI
10.1101/2022.04.22.489192
Open publication

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Ventral Hippocampal Infusions of C20:0 Ceramide Stimulate Microglia and Induce Anhedonia-like Behavior in Female and Male RatsDOI 10.1101/2022.04.22.489192
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