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Supraphysiologic doses of 17β-Estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolism

2023-05-08

Abstract excerpt

<h4>Background: </h4> 17β-Estradiol (E2) is generally considered neuroprotective in humans. However, the current clinical use of estrogen replacement therapy (ERT) is based on the physiological dose of E2 to treat menopausal syndrome and has limited therapeutic efficacy. The efficacy and potential toxicity of superphysiological doses of ERT for menopausal neurodegeneration are unknown. <h4>Methods: </h4> In this...

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Literature Corpus work
f906abd7-5b9d-5b25-95d5-0ac8cb3af046
DOI
10.21203/rs.3.rs-2875403/v1
Open publication

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Supraphysiologic doses of 17β-Estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolismDOI 10.21203/rs.3.rs-2875403/v1
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