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Article

Anxiety and Depression Are Related to Higher Activity of Sphingolipid Metabolizing Enzymes in the Rat Brain.

Cells - 17 May 2020

Zoicas Iulia, Mühle Christiane, Schmidtner Anna K, Gulbins Erich, Neumann Inga D, Kornhuber Johannes

Abstract excerpt

Changes in sphingolipid metabolism have been suggested to contribute to the pathophysiology of major depression. In this study, we investigated the activity of acid and neutral sphingomyelinases (ASM, NSM) and ceramidases (AC, NC), respectively, in twelve brain regions of female rats selectively bred for high (HAB) versus low (LAB) anxiety-like behavior. Concomitant with their highly anxious and depressive-like...

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Identifiers

PMID: 32429522
DOI: 10.3390/cells9051239
PMCID: PMC7290887

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